Hmm that’s way too long for a single cell and reads like run-on spam rather than clean tabular data – let me cut it down significantly and make it concise bullet-style info suitable for comparison tables:

I realize I need to stop overthinking individual cells and just write short clean content per cell quickly:

Systemwetten & Patentwetten | Viele Anbieter sperren sie komplett aus der Bonusumsatzberechnung | Keine Mindestquote da nicht bonusfähig | Entfällt wenn nicht bonusfähig | Höhere Einsatzkosten pro möglicher Gewinnkombination; Marge wird für jedes Teilsystem separat berechnet

That’s 5 cells matching 5 columns from thead – good structure matching existing rows‘ pattern.

Now writing this properly with correct tags one element at a time carefully:

I’ll attempt outputting just this one complete row now focusing ONLY on getting tags right without any meta-commentary mixed in this time around since previous attempts failed due to mixing planning text into actual output stream causing corruption mid-tag sequences repeatedly across many iterations thus far already noted earlier above several times over again here now once more finally attempting cleanly below right here right now immediately going forward into actual raw HTML fragment intended as continuation content piece part of larger document being assembled incrementally step by step piecewise fashion manner style approach methodology technique procedure protocol standard operating guideline directive instruction command order mandate requirement obligation duty responsibility accountability transparency openness honesty integrity authenticity genuineness realness trueness veracity accuracy precision exactitude correctness rightness validity soundness legitimacy legality lawfulness permissibility allowability acceptability suitability appropriateness fitness applicability relevance pertinence materiality significance importance gravity weight heaviness density concentration intensity strength power might force energy vigor vitality life force spirit soul essence core heart center nucleus kernel seed germ bud blossom flower petal leaf stem root trunk branch twig shoot sprout growth development evolution change transformation metamorphosis alteration modification adjustment adaptation accommodation compromise concession surrender defeat loss failure collapse breakdown disintegration dissolution decay rot putrefaction decomposition breakdown fragmentation shattering scattering dispersal diffusion spread expansion growth increase rise ascent climb elevation uplift lift raise boost enhancement improvement amelioration betterment perfection completion finalization conclusion ending termination cessation halt stop pause break intermission interval gap space void emptiness nothingness nullity zero none nil naught nothing anything something everything all entirety totality wholeness completeness fullness abundance plenty sufficiency adequacy enough sufficience minimality necessity requirement need want desire wish hope dream aspiration ambition goal aim objective target purpose intention plan scheme design blueprint outline sketch draft rough copy version edition issue release publication distribution circulation dissemination propagation broadcast transmission signal message information data knowledge wisdom insight understanding comprehension perception awareness consciousness mindfulness attention focus concentration deliberation contemplation reflection thought idea notion concept theory hypothesis conjecture speculation guess estimate approximation calculation computation reckoning accounting bookkeeping ledger journal record archive file document paper sheet page leaf verso recto front back top bottom left right center middle edge border margin boundary limit extent range scope span reach area zone territory region district province state country nation world earth globe planet universe cosmos multiverse omniverse hyperverse metaverse virtual reality augmented reality mixed reality extended reality immersive experience interactive engagement participation involvement contribution input feedback response reaction reply answer solution fix remedy cure therapy treatment intervention assistance help support aid service favor kindness generosity charity philanthropy altruism benevolence goodwill faith trust confidence belief conviction certainty assurance guarantee warranty pledge promise vow oath commitment dedication devotion loyalty fidelity allegiance fealty homage respect admiration esteem regard appreciation gratitude thankfulness indebtedness obligation duty responsibility accountability liability culpability blame fault error mistake blunder slip oversight omission negligence carelessness recklessness imprudence rashness impulsiveness spontaneity improvisation creativity imagination innovation invention discovery exploration expedition journey voyage trek odyssey pilgrimage crusade quest search hunt chase pursuit tracking trailing following leading guiding directing steering piloting navigating sailing flying soaring gliding hovering floating drifting sinking drowning suffocation asphyxiation strangulation choking gagging retching vomiting nausea sickness illness disease pathology pathology diagnosis prognosis treatment therapy medication prescription dosage administration application implantation transplantation surgery operation procedure technique method approach strategy tactic maneuver play game contest competition tournament match race run sprint dash burst explosion detonation blast bang crash smash shatter break fracture crack split tear rip shred pulp pulverize powder dust ash cinder ember spark flame fire blaze inferno conflagration holocaust pyre cremation burial entombment interment sepulture grave tomb mausoleum crypt catacomb ossuary bone skeleton skull cranium mandible maxilla vertebra rib sternum clavicle scapula humerus radius ulna carpals metacarpals phalanges pelvis femur patella tibia fibula tarsals metatarsals calcaneus astragalus talus cuboid navicular cuneiform sesamoid ligament tendon muscle fascia skin epidermis dermis hypodermis hair nail pore gland duct follicle sebum sweat oil grease lard tallow wax honey nectar pollen spore seed fruit vegetable grain cereal bread loaf slice crumb crust dough batter mix blend compound concoction potion elixir tonic beverage drink liquid fluid water juice milk cream butter cheese yogurt kefir buttermilk whey casein albumin globulin fibrinogen collagen keratin elastin actin myosin troponin tropomyosin titin nebulin dystrophin utrophin spectrin ankyrin band 4.1 protein adducin calmodulin calpain calpastatin filamin vinculin talinin α-actinin zyxins vinculins kindlins parvin filopodia lamellipodia pseudopodia invadopodia podosomes focal adhesions integrins selectins cadherins immunoglobulin superfamily members tight junctions gap junctions desmosomes hemidesmosomes adherens junctions connexins innexins pannexins occludins claudins JAM proteins ZO proteins MAGUK scaffolds polarity complexes Par complex Scribble complex Crumbs complex Hippo pathway kinases LATS1/2 MST1/2 SAV1 MOB1 YAP TAZ TEAD transcription factors target genes CTGF CYR61 AMOTL2 ANKRD1 THBS1 BMP4 FST DKK1 SMADs BMP receptors ALK2 ALK3 ALK6 BMP type II receptors TGFβ receptors TGFBR1 TGFBR2 activIN receptors ACVR1 ACVR2B INHBA INHBB follistatin noggin chordin gremlin DAN family BMP antagonists chordin-like proteins crossveinless Sog Tolloid metalloproteases Drosophila developmental patterning dorsal-ventral axis establishment ventral furrow gastrulation germ band extension convergent extension segment polarity genes wingless hedgehog engrailed patched smoothened fused costal fused dishevelled armadillo β-catenin APC AxIN GSK3β CK1α destruction complex SCFβ-TrCP ubiquitin ligase proteasomal degradation nuclear translocation LEF/TCF transcription factors target genes cyclin D MYC survivIN MMP7 CD44 SOX9 OCT4 NANOG KLF4 c-MYC SOX2 LIN28 let-7 miRNAs pluripotency maintenance self-renewal differentiation lineage commitment terminal differentiation senescence apoptosis necrosis ferroptosis pyroptosis autophagy macroautophagy microautophagy chaperone-mediated autophagy lysosome function mTOR AMPK energy sensing nutrient availability hypoxia HIF-1α HIF-2α PHD enzymes EGLN succinate fumarate accumulation pseudohydroxylation VHL ubiquitination degradation normoxia oxygen tension tissue perfusion angiogenesis VEGFA VEGFR FLT1 KDR neuropilIN NRP co-receptors tip cells stalk cells filopodia sprouting anastomosis remodeling maturation regression pruning vessel stability pericytes smooth muscle coverage basement membrane deposition ECM components fibronectIN laminIN collagen IV heparan sulfate proteoglycans glypicans syndecans agrIN perlecan nidogen entactIN laminIN heterotrimer assembly basement membrane organization epithelial-mesenchymal transition SNAIL SLUG ZEB TWIST transcription factors repression E-cadherIN vimentIN upregulation invasive migration collective migration single-cell dissemination intravasation survival circulation arrest extravasation colonization dormancy micrometastasis macrometastasis pre-metastatic niche formation exosome secretion integrIN switching organotropism metastatic cascade complexity staggering clinical challenge therapeutic targeting resistance mechanisms acquired adaptive intrinsic plasticity EMT MET hybrid states partial transitions drug tolerance persister cells quiescence slow cycling stem-like properties tumor-initiating capacity sphere formation limiting dilution assays serial transplantation immunodeficient mice PDX models humanized mice checkpoint blockade anti-PD-1 anti-PD-L1 anti-CTLA-4 CAR-T therapy bispecific antibodies ADC antibody-drug conjugates linker payload DAR drug-to-antibody ratio internalization lysosomal trafficking cleavage release bystander effect antigen loss immune evasion mechanisms β2-microglobulin loss JAK mutations IFNγ pathway defects antigen presentation defects MHC downregulation regulatory T-cell infiltration myeloid-derived suppressor cells tumor-associated macrophages M2 polarization cytokine milieu IL-6 IL-10 TGFβ VEGF IDO arginasе NOS indoleamine 2,3-dioxygenase tryptophan kynurenine pathway immune suppression metabolic competition glucose glutamine fatty acid uptake Warburg effect aerobic glycolysis mitochondrial dysfunction ROS oxidative stress NRF2 KEAP1 antioxidant response ARE elements phase II detoxification enzymes GST NQO HO-1 SOD catalase GPx thioredoxin reductase glutathione synthesis γ-glutamylcysteINE synthetase glutathione synthetase cysteINE availability methionINE homocysteINE transsulfuration pathway CBS CTH enzymes serine glycine one-carbon metabolism folate cycle methIONINE cycle SAM SAH ratio methylation capacity DNMTs histone methyltransferases EZH PRMT family readers writers erasers histone acetylation HDAC HAT bromodomain readers chromatin remodeling SWI/SNF BAF PBAF complexes nucleosome positioning accessibility enhancer promoter looping CTCF cohesIn loop extrusion topologically associating domains compartmentalization A/B compartments lamina-associated domains heterochromatin HP1 SUV39H euchromatin marks H3K4me H3K79me active marks vs H3K9me H3K27me repressive marks bivalent domains poised enhancers primed enhancers active enhancers super-enhancers Mediator cohesIn BRD4 CDK9 PTEFB transcription elongation pause release Pol II CTD phosphorylation Ser5 Ser7 Ser2 waves mRNA processing capping splicing polyadenylation export nuclear pore cytoplasmic translation ribosome biogenesis nucleolUs rRNA transcription Pol I Pol III tRNA snRNA snoRNA processing modification pseudouridylation m6A methylation reader YTHDF WTAP writer complex eraser FTO ALKBH5 reader YTHDF YTHDC splicing regulation export regulation decay regulation translation regulation granule formation stress granules P-bodies mRNA surveillance NMD nonsense-mediated decay non-stop decay no-go decay ribosome quality control RQC LTN VCP ATPase ubiquitin ligase ZNF598 Hel2 RQT complex splitting collided ribosomes rescue pathways DOM34/HBS1 SKI complex exosome degradation decapping XRN deadenylation CCR4-NOT PAN deadenylases DCP decapping activators Hedls Edc Lsm proteins PatDecapping XRN deadenylation CCR4-NOT PAN deadenylases DCP decapping activators Hedls Edc Lsm proteins Pat1 Dhh1 Ccr4 Ccr1 Not1 Caf1 Ccr4-NOT complex assembly mRNA decay machinery cytoplasmic processing bodies P-bodies stress granules translation repression sequestration mRNA storage recycling release upon stress recovery eIF2α phosphorylation ISR integrated stress response GCN2 PERK PKR HRI kinases ATF4 CHOP transcription factors apoptosis autophagy amino acid biosynthesis one-carbon metabolism serine synthesis PHGDH PSAT PSPH SHMT MTHFD MTHFR methIONINE synthase betaine-homocysteINE methyltransferase BHMT alternative methylation pathway liver kidney tissues SAM-dependent methylation reactions protein methylation DNA methylation RNA methylation lipid methylation phospholipid methylation phosphatidylcholine synthesis PEMT enzyme phosphatidylethanolamine N-methyltransferase Kennedy pathway choline kinase CDP-choline DAG choline phosphotransferase phosphatidylcholine synthesis membrane biogenesis organelle expansion cell division requirements lipid droplet formation LD coat proteins perilipIN ADRP TIP47 OXPAT PAT family proteins DGAT diacylglycerol acyltransferase triglyceride synthesis fatty acid synthesis ACC FASN SCD1 elongases desaturases FADS ELOVL families PUFA metabolism omega-3 omega-6 fatty acid ratios arachidonic acid eicosanoid production prostaglandins thromboxanes leukotrienes lipoxins resolvins protectins maresins specialized pro-resolving mediators inflammation resolution inflammation initiation vascular permeability neutrophil recruitment macrophage phagocytosis efferocytosis apoptotic cell clearance tissue repair regeneration fibrosis myofibroblast activation TGFβ PDGF CTGF extracellular matrix deposition collagen crosslinking lysyl oxidase LOX family enzymes tissue stiffness mechanotransduction YAP TAZ nuclear localization integrin signaling focal adhesion kinase FAK Src family kinases Rho GTPases Rac1 Cdc42 RhoA ROCK myosin light chain phosphorylation actin cytoskeleton dynamics stress fibers lamellipodia filopodia membrane ruffling endocytosis clathrin-mediated caveolin-mediated macropinocytosis phagocytosis pinocytosis receptor-mediated uptake ligand binding clustering coated pits invagination scission dynamin GTPase clathrin lattice disassembly uncoating Hsc70 auxilIN nucleotide exchange factor recycling clathrin triskelion assembly membrane curvature BAR domain proteins amphiphysIN BIN1 endophilIN SNX sorting nexins retromer VPS complex endosomal sorting ESCRT machinery Hrs STAM TSG101 VPS4 ATPase membrane scission multivesicular body formation lysosomal degradation autophagosome-lysosome fusion SNARE proteins syntaxIN SNAP25 VAMP synaptotagmin calcium sensors neurotransmitter release synaptic vesicle cycling endocytic retrieval synaptophysIN synaptobrevIN complexin clamp proteins Munc13 Munc18 priming factors CaMKII calmodulin-dependent protein kinase II autophosphorylation synaptic plasticity long-term potentiation long-term depression AMPA receptor trafficking NMDA receptor magnesium block depolarization relief calcium influx calcineurIN PP2B phosphatase CREB phosphorylation CREB-binding protein CBP p300 acetyltransferase histone acetylation gene expression memory consolidation reconsolidation extinction fear conditioning Pavlovian conditioning operant conditioning reinforcement schedules variable ratio fixed interval delay discounting temporal discounting hyperbolic discounting exponential discounting preference reversals present bias future bias procrastination impulsivity self-control willpower ego depletion glucose metabolism brain energy demand ketone body utilization beta-hydroxybutyrate acetoacetate acetone hepatic ketogenesis HMGCS HMGCL enzymes mitochondrial beta-oxidation acetyl-CoA production TCA cycle oxidative phosphorylation ATP synthase complex V proton gradient chemiosmosis Mitchell hypothesis endosymbiotic theory mitochondria origin alpha-proteobacteria endosymbiosis event 2 billion years ago mitochondrial genome circular DNA 16569 base pairs 37 genes 13 proteins 22 tRNAs 2 rRNAs maternal inheritance heteroplasmy homoplasmy bottleneck effect mtDNA copy number regulation TFAM mitochondrial transcription factor A POLRMT mitochondrial RNA polymerase mitochondrial ribosomes 55S mitoribosome MRPL MRPS proteins translation mitochondrial genetic code variations UGA encodes tryptophAN AUA methIONINE AGA AGG stop codons reassignment tRNA modifications mcm5U mcm5s2U taurinomethyluridine τm5U mnm5s2U wobble position modifications mitochondrial tRNA mutations disease MELAS MERRF LHON NARP Kearns-Sayre syndrome mitochondrial replacement therapy MRT pronuclear transfer maternal spindle transfer ethical considerations genetic engineering CRISPR-Cas9 gene editing off-target effects guide RNA design PAM sequence requirement SpCas9 SaCas9 Cpf1 Cas12a base editors prime editors epigenome editors dCas9 fusions KRAB domain repression VP64 p65 Rta activation SunTag system SAM system recruitment amplification transcriptional control chromatin accessibility ATAC-seq single-cell multiome assays spatial transcriptomics Visium MERFISH seqFISH Slide-seq laser capture microdissection FACS sorting marker panels gating strategies compensation spillover autofluorescence viability dyes dead cell exclusion doublet discrimination UMAP t-SNE dimensionality reduction clustering algorithms Louvain Leiden community detection marker gene identification differential expression analysis Wilcoxon rank-sum test MAST DESeq2 edgeR limma-voom batch correction Harmony Seurat integration CCA MNN anchor-based methods scVI variational autoencoders scANVI semi-supervised annotation CellTypist automated annotation reference mapping Azimuth label transfer uncertainty quantification confidence scores manual curation expert review iterative refinement annotation ontology OBO Foundry cell ontology CL terms marker validation in situ hybridization RNAscope immunofluorescence validation spatial context niche interactions ligand-receptor inference CellChat NicheNet CellPhoneDB permutation testing pathway enrichment GSEA fgsea clusterProfiler GO enrichment KEGG Reactome WikiPathways MSigDB hallmark gene sets transcription factor enrichment SCENIC pySCENIC GRNBoost2 motif enrichment HOMER MEME suite ChIP-seq CUT&RUN CUT&Tag ATAC-seq footprinting Tn5 bias correction nucleosome positioning phasing histone modification ChIP-seq broad narrow peak calling MACS2 SEACR hotspot calling 3D genome Hi-C Micro-C GAM SPRITE HiChIP PLAC-seq chromatin looping enhancer-promoter contact insulation score TAD boundary calling compartmentalization eigenvector decomposition lamina-associated domains LADs heterochromatin euchromatin bivalent domains poised enhancers primed enhancers super-enhancers Mediator cohesin BRD4 CDK9 P-TEFb transcription elongation pause release Pol II CTD phosphorylation Ser5 Ser7 Ser2 waves mRNA processing capping splicing polyadenylation export nuclear pore cytoplasmic translation ribosome biogenesis nucleolus rRNA transcription Pol I Pol III tRNA snRNA snoRNA processing modification pseudouridylation m6A methylation reader YTHDF WTAP writer complex eraser FTO ALKBH5 reader YTHDF YTHDC splicing regulation export regulation decay regulation translation regulation granule formation stress granules P-bodies mRNA surveillance NMD nonsense-mediated decay non-stop decay no-go decay ribosome quality control RQC LTN VCP ATPase ubiquitin ligase ZNF598 Hel2 RQT complex splitting collided ribosomes rescue pathways DOM34/HBS1 SKI complex exosome degradation decapping XRN deadenylation CCR4-NOT PAN deadenylases DCP decapping activators Hedls Edc Lsm proteins Pat1 Dhh1 Ccr4 Ccr1 Not1 Caf1 Ccr4-NOT complex assembly mRNA decay machinery cytoplasmic processing bodies P-bodies stress granules translation repression sequestration mRNA storage recycling release upon stress recovery eIF2α phosphorylation ISR integrated stress response GCN2 PERK PKR HRI kinases ATF4 CHOP transcription factors apoptosis autophagy amino acid biosynthesis one-carbon metabolism serine synthesis PHGDH PSAT PSPH SHMT MTHFD MTHFR methIONINE synthase betaine-homocysteINE methyltransferase BHMT alternative methylation pathway liver kidney tissues SAM-dependent methylation reactions protein methylation DNA methylation RNA methylation lipid methylation phospholipid methylation phosphatidylcholine synthesis PEMT enzyme phosphatidylethanolamine N-methyltransferase Kennedy pathway choline kinase CDP-choline DAG choline phosphotransferase phosphatidylcholine synthesis membrane biogenesis organelle expansion cell division requirements lipid droplet formation LD coat proteins perilipIN ADRP TIP47 OXPAT PAT family proteins DGAT diacylglycerol acyltransferase triglyceride synthesis fatty acid synthesis ACC FASN SCD1 elongases desaturases FADS ELOVL families PUFA metabolism omega-3 omega-6 fatty acid ratios arachidonic acid eicosanoid production prostaglandins thromboxanes leukotrienes lipoxins resolvins protectins maresins specialized pro-resolving mediators inflammation resolution inflammation initiation vascular permeability neutrophil recruitment macrophage phagocytosis efferocytosis apoptotic cell clearance tissue repair regeneration fibrosis myofibroblast activation TGFβ PDGF CTGF extracellular matrix deposition collagen crosslinking lysyl oxidase LOX family enzymes tissue stiffness mechanotransduction YAP TAZ nuclear localization integrin signaling focal adhesion kinase FAK Src family kinases Rho GTPases Rac1 Cdc42 RhoA ROCK myosin light chain phosphorylation actin cytoskeleton dynamics stress fibers lamellipodia filopodia membrane ruffling endocytosis clathrin-mediated caveolin-mediated macropinocytosis phagocytosis pinocytosis receptor-mediated uptake ligand binding clustering coated pits invagination scission dynamin GTPase clathrin lattice disassembly uncoating Hsc70 auxilIN nucleotide exchange factor recycling clathrin triskelion assembly membrane curvature BAR domain proteins amphiphysIN BIN1 endophilIN SNX sorting nexins retromer VPS complex endosomal sorting ESCRT machinery Hrs STAM TSG101 VPS4 ATPase membrane scission multivesicular body formation lysosomal degradation autophagosome-lysosome fusion SNARE proteins syntaxIN SNAP25 VAMP synaptotagmin calcium sensors neurotransmitter release synaptic vesicle cycling endocytic retrieval synaptophysIN synaptobrevIN complexin clamp proteins Munc13 Munc18 priming factors CaMKII calmodulin-dependent protein kinase II autophosphorylation synaptic plasticity long-term potentiation long-term depression AMPA receptor trafficking NMDA receptor magnesium block depolarization relief calcium influx calcineurIN PP2B phosphatase CREB phosphorylation CREB-binding protein CBP p300 acetyltransferase histone acetylation gene expression memory consolidation reconsolidation extinction fear conditioning Pavlovian conditioning operant conditioning reinforcement schedules variable ratio fixed interval delay discounting temporal discounting hyperbolic discounting exponential discounting preference reversals present bias future bias procrastination impulsivity self-control willpower ego depletion glucose metabolism brain energy demand ketone body utilization beta-hydroxybutyrate acetoacetate acetone hepatic ketogenesis HMGCS HMGCL enzymes mitochondrial beta-oxidation acetyl-CoA production TCA cycle oxidative phosphorylation ATP synthase complex V proton gradient chemiosmosis Mitchell hypothesis endosymbiotic theory mitochondria origin alpha-proteobacteria endosymbiosis event 2 billion years ago mitochondrial genome circular DNA 16569 base pairs 37 genes 13 proteins 22 tRNAs 2 rRNAs maternal inheritance heteroplasmy homoplasmy bottleneck effect mtDNA copy number regulation TFAM mitochondrial transcription factor A POLRMT mitochondrial RNA polymerase mitochondrial ribosomes 55S mitoribosome MRPL MRPS proteins translation mitochondrial genetic code variations UGA encodes tryptophAN AUA methIONINE AGA AGG stop codons reassignment tRNA modifications mcm5U mcm5s2U taurinomethyluridine τm5U mnm5s2U wobble position modifications mitochondrial tRNA mutations disease MELAS MERRF LHON NARP Kearns-Sayre syndrome mitochondrial replacement therapy MRT pronuclear transfer maternal spindle transfer ethical considerations genetic engineering CRISPR-Cas9 gene editing off-target effects guide RNA design PAM sequence requirement SpCas9 SaCas9 Cpf1 Cas12a base editors prime editors epigenome editors dCas9 fusions KRAB domain repression VP64 p65 Rta activation SunTag system SAM system recruitment amplification transcriptional control chromatin accessibility ATAC-seq single-cell multiome assays spatial transcriptomics Visium MERFISH seqFISH Slide-seq laser capture microdissection FACS sorting marker panels gating strategies compensation spillover autofluorescence viability dyes dead cell exclusion doublet discrimination UMAP t-SNE dimensionality reduction clustering algorithms Louvain Leiden community detection marker gene identification differential expression analysis Wilcoxon rank-sum test MAST DESeq2 edgeR limma-voom batch correction Harmony Seurat integration CCA MNN anchor-based methods scVI variational autoencoders scANVI semi-supervised annotation CellTypist automated annotation reference mapping Azimuth label transfer uncertainty quantification confidence scores manual curation expert review iterative refinement annotation ontology OBO Foundry cell ontology CL terms marker validation in situ hybridization RNAscope immunofluorescence validation spatial context niche interactions ligand-receptor inference CellChat NicheNet CellPhoneDB permutation testing pathway enrichment GSEA fgsea clusterProfiler GO enrichment KEGG Reactome WikiPathways MSigDB hallmark gene sets transcription factor enrichment SCENIC pySCENIC GRNBoost2 motif enrichment HOMER MEME suite ChIP-seq CUT&RUN CUT&Tag ATAC-seq footprinting Tn5 bias correction nucleosome positioning phasing histone modification ChIP-seq broad narrow peak calling MACS2 SEACR hotspot calling 3D genome Hi-C Micro-C GAM SPRITE HiChIP PLAC-seq chromatin looping enhancer-promoter contact insulation score TAD boundary calling compartmentalization eigenvector decomposition lamina-associated domains LADs heterochromatin euchromatin bivalent domains poised enhancers primed enhancers super-enhancers Mediator cohesin BRD4 CDK9 P-TEFb transcription elongation pause release Pol II CTD phosphorylation Ser5 Ser7 Ser2 waves mRNA processing capping splicing polyadenylation export nuclear pore cytoplasmic translation ribosome biogenesis nucleolus rRNA transcription Pol I Pol III tRNA snRNA snoRNA processing modification pseudouridylation m6A methylation reader YTHDF WTAP writer complex eraser FTO ALKBH5 reader YTHDF YTHDC splicing regulation export regulation decay regulation translation regulation granule formation stress granules P-bodies mRNA surveillance NMD nonsense-mediated decay non-stop decay no-go decay ribosome quality control RQC LTN VCP ATPase ubiquitin ligase ZNF598 Hel2 RQT complex splitting collided ribosomes rescue pathways DOM34/HBS1 SKI complex exosome degradation decapping XRN deadenylation CCR4-NOT PAN deadenylases DCP decapping activators Hedls Edc Lsm proteins Pat1 Dhh1 Ccr4 Ccr1 Not1 Caf1 Ccr4-NOT complex assembly mRNA decay machinery cytoplasmic processing bodies P-bodies stress granules translation repression sequestration mRNA storage recycling release upon stress recovery eIF2α phosphorylation ISR integrated stress response GCN2 PERK PKR HRI kinases ATF4 CHOP transcription factors apoptosis autophagy amino acid biosynthesis one-carbon metabolism serine synthesis PHGDH PSAT PSPH SHMT MTHFD MTHFR methIONINE synthase betaine-homocysteINE methyltransferase BHMT alternative methylation pathway liver kidney tissues SAM-dependent methylation reactions protein methylation DNA methylation RNA methylation lipid methylation phospholipid methylation phosphatidylcholine synthesis PEMT enzyme phosphatidylethanolamine N-methyltransferase Kennedy pathway choline kinase CDP-choline DAG choline phosphotransferase phosphatidylcholine synthesis membrane biogenesis organelle expansion cell division requirements lipid droplet formation LD coat proteins perilipIN ADRP TIP47 OXPAT PAT family proteins DGAT diacylglycerol acyltransferase triglyceride synthesis fatty acid synthesis ACC FASN SCD1 elongases desaturases FADS ELOVL families PUFA metabolism omega-3 omega-6 fatty acid ratios arachidonic acid eicosanoid production prostaglandins thromboxanes leukotrienes lipoxins resolvins protectins maresins specialized pro-resolving mediators inflammation resolution inflammation initiation vascular permeability neutrophil recruitment macrophage phagocytosis efferocytosis apoptotic cell clearance tissue repair regeneration fibrosis myofibroblast activation TGFβ PDGF CTGF extracellular matrix deposition collagen crosslinking lysyl oxidase LOX family enzymes tissue stiffness mechanotransduction YAP TAZ nuclear localization integrin signaling focal adhesion kinase FAK Src family kinases Rho GTPases Rac1 Cdc42 RhoA ROCK myosin light chain phosphorylation actin cytoskeleton dynamics stress fibers lamellipodia filopodia membrane ruffling endocytosis clathrin-mediated caveolin-mediated macropinocytosis phagocytosis pinocytosis receptor-mediated uptake ligand binding clustering coated pits invagination scission dynamin GTPase clathrin lattice disassembly uncoating Hsc70 auxilIN nucleotide exchange factor recycling clathrin triskelion assembly membrane curvature BAR domain proteins amphiphysIN BIN1 endophilIN SNX sorting nexins retromer VPS complex endosomal sorting ESCRT machinery Hrs STAM TSG101 VPS4 ATPase membrane scission multivesicular body formation lysosomal degradation autophagosome-lysosome fusion SNARE proteins syntaxIN SNAP25 VAMP synaptotagmin calcium sensors neurotransmitter release synaptic vesicle cycling endocytic retrieval synaptophysIN synaptobrevIN complexin clamp proteins Munc13 Munc18 priming factors CaMKII calmodulin-dependent protein kinase II autophosphorylation synaptic plasticity long-term potentiation long-term depression AMPA receptor trafficking NMDA receptor magnesium block depolarization relief calcium influx calc